Find and Offer Help During Self Isolation

Get Involved
I need help
I can help
Amber A
United States
Added: 05.04.2020

I haven’t ben able to go to the gym because of the virus, and so I’m looking for someone to lead me through work-outs through Skype or some other video platform. Trying to stay accountable.

See details
Share on Facebook
Tweett
Ethel Frye
United States
Added: 03.04.2020

My grandma is 82 years old. She lives alone, her sight is weak, and she can’t cook anymore. I am stuck in London on quarantine, so I am very nervous about her well-being and mental state. She is now staying at home in Norfolk, VA. I am looking for someone to cook her a nice meal, deliver it, and have a little warm chat with my granny. All of the items will be paid for separately.

See details
Share on Facebook
Tweett
Alice C. Lambert
United States
Added: 03.04.2020

Hello, I am a 67 years old woman living in Union County, New Jersey, and I must confess, I am really feeling the brunt of this quarantine. I have had a series of medical conditions over the last few years that have left me confined to a wheelchair and left my health, not at 100 percent.

I’m quickly running low on my meds and other home supplies, and I’m seriously terrified of going out to get some, as I have learned that older people are more likely to experience fatal complications from the Covid-19 Virus.

I am alone and well right now, but in need of quick help. I need someone who can regularly help with my shopping; this will include my medication, groceries, and other home supplies. I’ll be most grateful.

See details
Share on Facebook
Tweett

Find Help

Access highly rated helpers that want to help you during your self-isolating.

Offer Help

Tell about how you could help people to stay at home during their quarantine.

Post for free

Post jobs for free to connect with people in your area and help each other.

Coronavirus protease entry table

Protease inhibitors targeting coronavirus and filovirus entry. 2019–20 coronavirus pandemic - Potential repurposing candidates for 2019-nCoV Since the two domains are not held covalently, the S1 domain may be shed from the S2 stalk domain of the protein.. Characterization of severe acute respiratory syndrome-associated coronavirus SARS-CoV spike glycoprotein-mediated viral entry. A mixture of the target virus [e. The Vatican announced that Holy Week observances in Rome, which occur during the last week of the Christian penitential season of Lent , have been cancelled. In both serotypes I and II, FCoV exists as two biotypes or pathotypes that display extremely contrasting pathogenicity. Due to structural similarities between coronavirus S NTD and host cell proteins, it has been suggested that the NTD emerged from acquisition of a host sugar-binding galectin-like domain in an ancestral coronavirus Peng et al. Please review our privacy policy. Table 2 Structure and antiviral activity of K analogs modified at the P3 position.https://www.cdc.gov/coronavirus/index.html

In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases. The respective enzymes are thus excellent targets for antiviral www.qarantino.com by: Feb 27,  · ASC09 is an experimental HIV-1 protease inhibitor; ritonavir and lopinavir/ritonavir are approved protease inhibitors for HIV/AIDS; umifenovir is an approved entry inhibitor against influenzaCited by: 2. Apr 16,  · Coronavirus entry is largely controlled by the spike surface envelope glycoprotein (S) since it bears both receptor binding and membrane fusion capabilities (Masters and Perlman, ). As such, the S glycoprotein is a crucial determinant of tissue and cell tropism as well as host www.qarantino.com by:

Protease inhibitors targeting coronavirus and filovirus entry Lopinavir; A Potent Drug against Coronavirus Infection: Insight from Molecular Docking Study Several proteases such as tryptase clara, can selectivity cleave the consensus cleavage https://www.cdc.gov/coronavirus/index.html of human influenza A virus envelope glyco. To extract the binding site residues of each inhibitor, the best https://www.cdc.gov/coronavirus/index.html complex was analyzed by Argus-Lab 4. Introduction Further establishing the usefulness of entfy system HCoV-HKU1 was https://www.cdc.gov/coronavirus/index.html for the first time in ciliated cells of bronchial HAE cultures in after culturing it in conventional cell lines had failed [ 26 ]! 2, Table 1). The TMPRSS2 inhibitor camostat, for example, has been identified as a potential therapeutic agent for coronaviruses such as SARS-CoV and MERS-. Coronaviruses have a non-structural protein – a protease – which is able to PDB entry 5N5O[xvii], a structure of SARS coronavirus main protease deposited by nCoV protease are listed in the following table – after further inspection. Table 2. Proteolytic processing of the SARS-CoV spike protein important for cell-​cell. fusion and/or virus entry. The table summarizes the different proteases. Spike protein fusion Peptide and feline coronavirus virulence.