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Amber A
United States
Added: 05.04.2020

I haven’t ben able to go to the gym because of the virus, and so I’m looking for someone to lead me through work-outs through Skype or some other video platform. Trying to stay accountable.

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Ethel Frye
United States
Added: 03.04.2020

My grandma is 82 years old. She lives alone, her sight is weak, and she can’t cook anymore. I am stuck in London on quarantine, so I am very nervous about her well-being and mental state. She is now staying at home in Norfolk, VA. I am looking for someone to cook her a nice meal, deliver it, and have a little warm chat with my granny. All of the items will be paid for separately.

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Alice C. Lambert
United States
Added: 03.04.2020

Hello, I am a 67 years old woman living in Union County, New Jersey, and I must confess, I am really feeling the brunt of this quarantine. I have had a series of medical conditions over the last few years that have left me confined to a wheelchair and left my health, not at 100 percent.

I’m quickly running low on my meds and other home supplies, and I’m seriously terrified of going out to get some, as I have learned that older people are more likely to experience fatal complications from the Covid-19 Virus.

I am alone and well right now, but in need of quick help. I need someone who can regularly help with my shopping; this will include my medication, groceries, and other home supplies. I’ll be most grateful.

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Ribosomal frameshifting coronaviruses

Altering SARS Coronavirus Frameshift Efficiency Affects Genomic and Subgenomic RNA Production Structure of Coronavirus nCoV 2019/2020 While many sequences involved in coronavirus subgenomic RNA synthesis have been elucidated, sequences and structures involved in regulating coronavirus genomic RNA synthesis are less well defined [ 24 ]. 1. Introduction The typical organization of the genome is. Obviously silent protein coding mutations are preferable so that only recoding events are analyzed rather than protein function. Ribosomal frameshifting The 5′ Gag and 3′ Pol open reading frames overlap by nt. Most ribosomes translating Gag terminate at the Gag termination codon, but about 1% of ribosomes translating Gag perform a − 1 ribosomal frameshift at a special sequence into the Pol open reading frame and synthesize a Gag–Pol fusion protein (Dinman et al., ; Fujimura & Wickner, a; Icho & . Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, an unusually large RNA genome, and a unique replication strategy. Programmed ribosomal frameshifting (PRF) is a translational recoding phenomenon historically associated with viruses and retrotransposons. PRF signals are cis -acting elements embedded in mRNAs that stochastically redirect translating ribosomes into a new reading frame (i.e., by + 1 or − 1 nucleotide). Dinman JD Ribosomal frameshifting in yeast viruses.

A mechanical explanation of RNA pseudoknot function in | FPrime Protein-directed ribosomal frameshifting temporally regulates gene expression Outbreaks sometimes result in diarrhea and loss of livestock. Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. To discover ligands for the SARS-pseudoknot by virtual screening, we constructed a 3D structural model of the SARS-pseudoknot and conducted a computational screening of the chemical database. UniProt release 2020_01 After endocytosis the viral genome is released B. Programmed −1 ribosomal frameshifting (PRF) and stop codon readthrough are such as the frameshift stimulator pseudoknot in human coronavirus E that. Programmed ribosomal frameshifting is an essential mechanism used for the expression of orf1b in coronaviruses. Comparative analysis of the. In molecular biology, the coronavirus frameshifting stimulation element is a conserved stem-loop of RNA found in coronaviruses that can promote ribosomal​. A, and mature viral proteins bott.